Chondrocyte mechanical stress
WebNov 17, 2016 · Mechanical stress has also been reported in chondrocytes, but the present study focused on the effects of biomechanical stress on the cell phenotype and … WebMar 23, 2016 · Mechanical stress plays an important role in the initiation and progression of osteoarthritis. Studies show that excessive mechanical stress can directly damage …
Chondrocyte mechanical stress
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WebDec 13, 2024 · Chondrocytes were stressed with MT-specific inhibitors rotenone and antimycin (Rot/A), then co-cultured with MSCs for up to 8 h at physiologic oxygen concentration for chondrocytes (5% O 2; Fig. 1... WebFeb 11, 2024 · Bone Research - IκB-ζ signaling promotes chondrocyte inflammatory phenotype, senescence, and erosive joint pathology ... ranging from mechanical stress to stimulation by inflammatory cytokines, ...
WebMechanical stress on weight-bearing bones plays a large part in bone remodeling. What single factor plays the largest role in maintaining adequate bone strength? Bone length Gravity Vitamin E Cartilage Gravity Which bone would be formed by the process of intramembranous ossification? Mandible of the lower jaw Vertebra of the spine WebNov 30, 2024 · Post-traumatic osteoarthritis can develop as a result of the initial mechanical impact causing the injury and also as a result of chronic changes in mechanical loading of the joint. Aberrant mechanical loading initiates excessive production of reactive oxygen species, oxidative damage, and stress that appears to damage mitochondria in the …
WebAug 17, 2024 · Tensile stress is known to regulate chondrocyte behaviors such as ECM production, proliferation, and their mechanical properties [26,27,28]. The effects of tensile stress on growth plate or articular chondrocytes were tested with 2D cell stretching devices. WebProtective effects of cilengitide on inflammation in chondrocytes under excessive mechanical stress Authors Naoto Hirose 1 , Yuki Okamoto 2 , Makoto Yanoshita 2 , Yuki Asakawa 1 , Chikako Sumi 2 , Mami Takano 1 , Sayuri Nishiyama 1 , Shao-Ching Su 1 , Tomomi Mitsuyoshi 1 , Ryo Kunimatsu 2 , Kazuo Tanne 1 , Kotaro Tanimoto 1 Affiliations
WebJul 1, 2024 · Here, we investigated the potential role of TRPV4 in chondrocyte apoptosis induced by excessive mechanical stress. Main methods: Primary chondrocytes were …
WebAug 16, 2024 · Failing of intrinsic chondrocyte repair after mechanical stress is known as one of the most important initiators of osteoarthritis. Nonetheless, insight into these early mechano-pathophysiological processes in age-related human articular cartilage is still lacking. Such insights are needed to advance clinical development. city of cookeville tn waterWebJan 1, 2024 · Articular chondrocytes are largely postmitotic with their metabolism being stimulated by physiological magnitudes of mechanical load, inducing biosynthesis of molecules to preserve the tissue integrity and maintain a balance … don heatrick weight cutWebChondrocytes effectively respond to mechanical stresses either ‘directly’ through sensing PCM deformation via cell–ECM adhesions and/or cell sensory structures, or ‘indirectly’ following the... don hearts cdWebIn a mouse model of OA induced by mechanical stress, researchers found that the expression of HIF-1α decreased and the expression of caspase 3 increased in the chondrocytes of OA mice and concluded that the HIF-1α signal might participate in chondrocyte apoptosis by inhibiting the caspase cascade and slowing down the … don heaneyWebA better understanding of molecular events following cartilage injury is required to develop treatments that prevent or delay the onset of trauma-induced osteoarthritis. In this study, alterations to SIRT1 activity in bovine articular cartilage explants were evaluated in the 24 h following a mechanical overload, and the effect of pharmacological SIRT1 activator … city of cookeville waterWebApr 1, 2024 · Articular chondrocytes occupy a dynamic mechanical environment facing a complex and regular combination of shear stress, compression, osmotic stress, hydrostatic pressure and tensile stretch … don heath facebook memorialWebApr 6, 2024 · Mitochondrial dynamics, coupled with mitophagy, is critical for the maintenance of mitochondrial fitness, involving many cellular processes, such as proliferation and apoptosis. Excessive mechanical stress induces chondrocyte apoptosis; however, the effects of mechanical stress on mitochondrial dynamics remain elusive. don heath forest city nc