Cisplatin and apoptosis

Author: opdp

August undefined, 2024

WebAug 6, 2015 · It has been reported that cisplatin induces the expression of p53, which plays diverse roles, particularly in regulating glycolysis genes [ 8 – 11 ]. Down-regulation of glycolysis genes when p53 is over-expressed leads to apoptosis. Moreover, energy status of cell is the main determining factor in cell survival or cell death.

Cisplatin Cancer information Cancer Research UK

WebMay 1, 2008 · Interestingly, cisplatin can also induce necrosis and apoptosis in cultured endothelial cells, although evidence is yet to be demonstrated for endothelial cell apoptosis during cisplatin nephrotoxicity in vivo. 44 APOPTOTIC PATHWAYS IN CISPLATIN NEPHROTOXICITY WebDec 17, 2024 · In cisplatin-induced acute kidney injury (AKI) or nephrotoxicity, autophagy is rapidly induced in renal tubular epithelial cells and acts as a cytoprotective mechanism for cell survival. Both mTOR and AMPK have been implicated in the regulation of autophagy in cisplatin-induced AKI. greeneville tn commons

Synergism of cisplatin-oleanolic acid co-loaded calcium carbonate ...

WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in … WebNational Center for Biotechnology Information WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 … greeneville tn county clerk

Molecular mechanisms of cisplatin resistance Oncogene - Nature

Targeted therapy for cisplatin‐resistant lung cancer via …

WebJan 29, 2024 · Apoptosis and necroptosis were previously reported to be the major pathological processes of acute kidney injury, however, preclinical works using specific inhibitor of neither apoptosis or... WebAim: To investigate the synergetic effect and the mechanism of antitumor action of the antibiotic lidamycin in combination with cisplatin in vitro. Methods: Cytotoxicity of the drugs was measured by clonogenic assay. Chromatin condensation was observed by co-staining with fluorescent dyes, Hoechst 33342 and propidium iodide. Apoptotic sub-G1 was … fluidmaster 7150w fht dishwasher 9WebLTTs minimise cisplatin-induced DNA damage and evade apoptosis by increased expression of anti-apoptotic factors. The observed diversity among the four LTTs … greeneville tn community calendar

"WebWe have treated four prostate tumor cell lines, DU-145, PC-3, LNCaP and 22RV1 with various concentrations of cisplatin in order to check for influence on viability and for onset of apoptosis induction. At a cisplatin concentration of 20 microM, 22RV1 and DU-145 cells showed approximately 22% and 18% … " - Cisplatin and apoptosis

Cisplatin and apoptosis

LncRNA UCA1 Enhances Cisplatin Resistance by Regulating …

WebLTTs minimise cisplatin-induced DNA damage and evade apoptosis by increased expression of anti-apoptotic factors. The observed diversity among the four LTTs highlights the complexity of cisplatin resistance mechanisms even within one tumour entity, explaining heterogeneity in patient responses to chemotherapy. WebThe cardiotoxic effect of chemotherapeutic agents as cisplatin has become a major issue recently. Interference with mitochondrial dynamics, biogenesis, redox status, and …

Did you know?

WebCisplatin is a widely used chemotherapeutic agent. Here we show that cisplatin induces apoptosis in renal collecting duct-derived cells (MDCK-C7 cells, resembling principal … WebOct 5, 2014 · Because cisplatin is a DNA-damaging agent and an inducer of apoptosis, it is reasonable to expect changes in HSPs in the development of cellular resistance …

WebMar 15, 2013 · The antineoplastic agent cis-diammineplatinum (II) dichloride (cisplatin, CDDP) is part of the poorly effective standard treatment of non-small cell lung carcinoma (NSCLC). Here, we report a novel strategy to improve the efficacy of CDDP. WebSynergistic killing of lung cancer cells by cisplatin and radiation via autophagy and apoptosis Synergistic killing of lung cancer cells by cisplatin and radiation via autophagy and apoptosis Authors Min Liu 1 , Shumei Ma 2 , Mingbo Liu 2 , Yufei Hou 2 , Bing Liang 2 , Xu Su 3 , Xiaodong Liu 4 Affiliations

WebThe manuscript by Bernardo-Bermejo analyses the metabolic differences between apoptotic bodies released by HK-2 cells, upon induction to apoptosis either by cisplatin or UV light. Although the topic may be potentially of interest, the manuscript is unclear, as well as the main findings. In addition, some methodological issues need to be addressed. WebTo further confirm that CYP1B1 is the executor of the UCA1/miR-513a-3p/CYP1B1 molecular axis regulating GC cell apoptosis induced by cisplatin, we simultaneously knocked down UCA1 and overexpressed CYP1B1 in GC cells, or knocked down both CYP1B1 and miR-513a-3p, finding that overexpression of CYP1B1 reduced …

WebMar 29, 2024 · In addition to TNF-α mediated apoptosis, cisplatin activates the p53 pathway, which can be a result of elevated ROS or induced as a response to elevated ROS from the intrinsic pathway. Treatment with cisplatin results in an increased expression and activation of the p53 protein since it regulates apoptosis of proximal tubular cells via ...

WebOct 13, 2024 · Stress responses, including autophagy, cell-cycle arrest, senescence, apoptosis, programmed necrosis and inflammation have key roles in the pathogenesis … greeneville tn coffee shopWebDec 12, 2024 · Our results show that administration of AAV-PSTPIP2 or epithelial cell-specific overexpression of PSTPIP2 reduces cisplatin-induced kidney dysfunction and inhibits apoptosis of renal tubular... greeneville tn community hospitalWebThe cardiotoxic effect of chemotherapeutic agents as cisplatin has become a major issue recently. Interference with mitochondrial dynamics, biogenesis, redox status, and apoptosis are the most possible underlying mechanisms. Semaglutide is a human glucagon-like peptide-1 receptor agonist (GLP-1R), w … greeneville tn county clerk\u0027s officeWebIn summary, a growing body of evidence suggests that cisplatin-induced cell death does not always come from "classic"apoptosis. Depending on both cisplatin dose and cellular … greeneville tn classifiedsWebActivated P13K/Akt/mTOR pathway attenuates the antitumor effects of chemotherapeutics leading to cancer cells survival and its proliferation, 53 which plays a pivotal role in … greeneville tn county clerk officeWebAbstract Cisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. ... fluidmaster american standard repair partsWebSep 5, 2011 · Bcl-2 blocks cisplatin-induced apoptosis and predicts poor outcome following chemoradiation treatment in advanced oropharyngeal squamous cell carcinoma. Clin Cancer Res 15: 1645–1654. fluidmaster 7530p8 better than wax