Impower 133 trial

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August undefined, 2024

Witryna28 wrz 2024 · The occurrence of irAEs in the immunotherapy arm was 41% in IMpower133, which is higher than historical data, and 20% in the CASPIAN trial. A … Witryna17 gru 2024 · IMpower133 was a randomized, double-blind, placebo-controlled phase 3 trial for patients with treatment-naїve extensive-stage small cell. Over 400 patients received standard carboplatin and...

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Witryna5 maj 2016 · A Study of Carboplatin Plus Etoposide With or Without Atezolizumab in Participants With Untreated Extensive-Stage (ES) Small Cell Lung Cancer (SCLC) … WitrynaThe results of the IMpower 133 trial support new indications for immunotherapy — first-line treatment of extensive-stage SCLC. It is the first improvement in the field of SCLC within the last 20 years and has the potential to impact daily practice, especially in well-de-veloped countries. However, the gain obtained with sogeti architectuur

IMpower, CASPIAN, and more: exploring the optimal first-line ...

WitrynaIn the Impower-133 study , only 11% (22 patients) received PCI, while the CASPIAN trial only allowed PCI on the control arm, of which 8% (21 patients) received it. Subgroup analyses of these trials suggest some intracranial efficacy of immunotherapy. Witryna31 sty 2024 · January 31, 2024 - The latest data from the IMpower133 trial shows that maintenance therapy with atezolizumab plus carboplatin and etoposide improves … Witryna20 maj 2024 · Mark Socinski, MD: IMpower133 was a very simple design. It took the standard-of-care regimen of carboplatin and etoposide as the control arm. It was placebo controlled. It gave 4 cycles of treatment, which is my standard followed by placebo maintenance. The investigational arm simply added atezolizumab to the combination … slow speaking spanish news

Atezolizumab for First-Line Treatment of PD-L1–Selected …

Small cell lung cancer patients treated with immune checkpoint ...

Witryna11 gru 2024 · Let’s talk about the IMpower133 trial with carboplatin, etoposide, and atezolizumab. Could you please go over the study design and the results from that … Witryna5 gru 2024 · First-line atezolizumab plus chemotherapy in treatment of extensive small cell lung cancer: a cost-effectiveness analysis from China Atezolizumab combination … slow speaking spanish translatorWitrynapatients. The IMpower 133 trial comprised only 10% of patients aged over 75 years. The regimen doses used in the IMpower 133 trial were carboplatin at a dose equivalent to an AUC of 5 and etoposide 100 mg/m2, which are higher doses than commonly used in clinical practice. The CAS-PIAN trial was a randomized phase 3 trial conducted to sogeti high tech gmbh

"WitrynaIMpower133 (NCT02763579), a global phase I/III, double-blind, randomized, placebo-controlled trial, showed that adding atezo (anti–PD-L1) to 1L carboplatin + etoposide … " - Impower 133 trial

Impower 133 trial

A Study of Carboplatin Plus Etoposide With or Without …

Witryna11 kwi 2024 · More recently, the addition of programmed death-ligand (PD-L1) inhibitors such as atezolizumab and durvalumab to established chemotherapy has led to an improvement in overall survival in patients with ES-SCLC, as demonstrated in the IMpower-133 trial and the CASPIAN trial [6,7,8]. Witryna19 lut 2015 · Atezolizumab plus bevacizumab and chemotherapy in non-small-cell lung cancer (IMpower150): key subgroup analyses of patients with EGFR mutations or baseline liver metastases in a randomised, open-label phase 3 trial. Lancet Respir Med. 2024 May;7(5):387-401. doi: 10.1016/S2213-2600(19)30084-0. Epub 2024 Mar 25.

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WitrynaBevacizumab combined with chemotherapy is approved for the treatment of metastatic nonsquamous NSCLC. 1,12,13 In addition to the known antiangiogenic effects of bevacizumab, 14 the inhibition of ... Witryna17 gru 2024 · We had the IMpower133 where everybody looked and said, “They are positive, but I still want more.” And then we had the negative string of results from the maintenance and the relapse, which was a...

WitrynaAtezolizumab in combination with carboplatin plus nab-paclitaxel chemotherapy compared with chemotherapy alone as first-line treatment for metastatic non … WitrynaNeither the IMpower 133 trial nor the CASPIAN trial collected information for the quality of life for patients with ES-SCLC. According to the previously published economic evaluation, the PFS and PS health states in our model were assigned the utilities of 0.673 and 0.473, respectively (15, 16).

Witryna4 wrz 2024 · Randomized phase III trials demonstrated that the combination of atezolizumab (IMpower-133) or durvalumab (CASPIAN) with platinum-etoposide … WitrynaPrincipal Investigator: Zamzam Al- Hashami ResearchGate, the professional network for scientists

WitrynaAlthough the phase II CITYSCAPE-02 trial found objective response rate (ORR) and progression-free survival (PFS) of non-small cell lung cancer (NSCLC) patients improved when tiragolumab was added to atezolizumab and chemotherapy, the phase III SKYSCRAPER-02 failed to find PFS or OS benefit in patients with SCLC. …

Witryna10 kwi 2024 · In this trial, the median follow-up duration was 12 months, and the median overall survival was significantly prolonged with the use of this agent to 15.4 months compared with 10.9 months with chemotherapy alone. ... But more importantly, especially after the results from the IMpower 133 trial, we now know that the small cell lung … slow speaking spanish podcastsWitrynaBetween IMPOWER 133 and CASPIAN trials, there were higher reported immune-related toxicities with the atezolizumab vs. durvalumab. However, the differences in the toxicities between the two anti-PDL1-containing regimens may be related to the design of the trials rather than the differences in tolerability between the drugs. IMPOWER 133 … sogeti officesWitryna17 gru 2024 · IMpower133 was a randomized, double-blind, placebo-controlled phase 3 trial for patients with treatment-naїve extensive-stage small cell. Over 400 patients … sogetim chatenay malabryWitryna6 gru 2024 · Methods: We conducted this double-blind, placebo-controlled, phase 3 trial to evaluate atezolizumab plus carboplatin and etoposide in patients with extensive … sogeti healthcareWitryna11 kwi 2024 · BackgroundProgrammed cell death-ligand 1 (PD-L1) inhibitors plus chemotherapy have made substantial progress in extensive-stage small-cell lung cancer (ES-SCLC), but the survival benefit is still limited. This study aimed to evaluate the preliminary efficacy and safety of camrelizumab plus platinum-irinotecan (IP/IC) … sogeti high tech issy les moulineauxWitryna10 kwi 2024 · Background: We aimed to evaluate the prognostic value of imaging biomarkers on 18F-FDG PET/CT in extensive-stage small-cell lung cancer (ES-SCLC) patients undergoing first-line chemo-immunotherapy. Methods: In this multicenter and retrospective study, we considered two cohorts, depending on the type of first-line … sogeti smart workspaceWitrynaThe IMpower133 trial evaluated the efficacy and safety of adding atezolizumab or placebo to first-line treatment with carboplatin and etopo-side in patients with … sogeti high tech lyon