Thiopental induction
WebThiopental is a barbiturate induction agent that can be administered by the IV or rectal route. The dose required for IV induction varies with age. Several studies 145, 146 confirmed previous findings by Cote and colleagues 147 and Brett and Fisher, 148 who showed that thiopental requirements are higher in children (Fig.13-3). Barbiturates ... WebSep 20, 2013 · After a single bolus, thiopental is rapidly distributed to highly perfused, low volume tissue (e.g. brain and spinal cord) and is then more slowly redistributed to lean muscle tissue, which terminates the initial effect of the induction dose. The uptake of thiopental by adipose tissue is a minor contributor to termination of the effects of an ...
Thiopental induction
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WebMar 16, 2024 · Five hundred consecutive electroconvulsive treatments were performed with thiopental induction; of these 7 were incomplete and not readable, reducing the series to 493. Atropine, 0.6 mg., was ... WebApr 7, 2024 · 2 mg/Kg thiopental + 0.5 ug/Kg fentanyl + 0.05 mg/Kg midazolam for induction of anesthesia. Endotracheal tube will be inserted aided by 1 mg/Kg succinyl choline. Patients will undergo surgical procedure to eliminate the source of sepsis e.g. abdominal exploration.
WebThiopental 5–15 Will cause tissue necrosis and phlebitis if extravasated; causes respiratory and cardiovascular depression Currently unavailable in the US Ketamine + Midazolam or Diazepam 2–5 0.1–0.4 Ketamine used alone causes muscle rigidity and could potentially exacerbate some types of seizures and tachyarrhythmias. Webinduction of anaesthesia; intubation in the head injured patient; treatment of intracranial hypertension; status epilepticus; This is a Tier 3 drug and only approved physicians may order. Dose: Loading Dose. 2-3 mg/kg for barbiturate-induced coma (for seizures or ICP) Maintenance Dose: infusion 3-5 mg/kg/hour (doses may be as high as 15mg/kg/hour)
Webity, similar to the effects of thiopental.15 Thiopental is an ultra–short-acting barbiturate that is used for the induction of anesthesia.16 The administration of thio-pental is associated with rapid induction and recovery from anesthesia, but it may increase heart rate and tran-siently decrease myocardial contractility.17 Etomidate is WebDec 31, 2024 · For thiopental, when used for induction of anesthesia for cesarean section, the highest concentration of thiopental in breast milk was in the first nursing after anesthesia, about 0.9 mg/L. Breastfeeding can be resumed as soon as the mother has recovered sufficiently from general anesthesia. However, if a combination of drugs is …
WebApr 10, 2024 · In conclusion, frontal spectral EEG analysis demonstrated that propofol induction maintained a deeper anesthesia than thiopental in pregnant women. Introduction Neuraxial anesthesia is a preferred ...
WebMay 18, 2024 · Ideally, the peak effect of these medications should be reached shortly before the time of induction. Test Dose. It is advisable to inject a small “test” dose of 25 to 75 mg (1 to 3 mL of a 2.5% solution) of Pentothal (Thiopental Sodium for Injection) to assess tolerance or unusual sensitivity to Pentothal, and pausing to observe patient ... inclusion\u0027s bwWebMedian time from seizure onset to first antiepileptic drug was 60 min [IQR, 35-90]. Reasons for intubation were coma in 95 (98%), acute respiratory distress in 18 (19%), refractory convulsive status epilepticus in 9 (9%), and shock in 6 (6%) patients; 50 (52%) patients had more than one reason. inclusion\u0027s btWebWhen used for induction in balanced anesthesia with a skeletal muscle relaxant and an inhalation agent: ... After a test dose, thiopental is injected at a slow rate of 100 mg/min (4 mL/min of a 2.5% solution) with the patient counting backwards from 100. Shortly after counting becomes confused but before actual sleep is produced, the injection ... incarnation jb-7WebAug 29, 2024 · Induction of anaesthesia; Treatment of status epilepticus; Neuroprotection; ADMINISTRATION / DOSING. IV or PR; RSI: 3-7 mg/kg IV can give in divided doses and lasts 5-15 min; PR: 1 g per 22 kg of bodyweight –> acts within 15 min; Elevated ICP 1-2 mg/kg IV as required; For thiopentone coma dosing, please see below inclusion\u0027s bzAnesthesia Sodium thiopental is an ultra-short-acting barbiturate and has been used commonly in the induction phase of general anesthesia. Its use has been largely replaced with that of propofol, but may retain some popularity as an induction agent for rapid-sequence induction and intubation, such as in … See more Sodium thiopental, also known as Sodium Pentothal (a trademark of Abbott Laboratories), thiopental, thiopentone, or Trapanal (also a trademark), is a rapid-onset short-acting barbiturate general anesthetic. … See more Sodium thiopental is a member of the barbiturate class of drugs, which are relatively non-selective compounds that bind to an entire superfamily of ligand-gated ion channels, … See more Thiopental rapidly and easily crosses the blood–brain barrier as it is a lipophilic molecule. As with all lipid-soluble anaesthetic drugs, the short duration of action of sodium thiopental is due almost entirely to its redistribution away from central circulation … See more Thiopental should be used with caution in cases of liver disease, Addison's disease, myxedema, severe heart disease, severe hypotension, a severe breathing disorder, or a family history of See more Following a shortage that led a court to delay an execution in California, a company spokesman for Hospira, the sole American manufacturer of the drug, objected to the use of thiopental in lethal injection. "Hospira manufactures this product because it … See more The usual dose range for induction of anesthesia using thiopental is from 3 to 6 mg/kg; however, there are many factors that can alter this. Premedication with sedatives such as See more As with nearly all anesthetic drugs, thiopental causes cardiovascular and respiratory depression resulting in hypotension, apnea, and airway obstruction. For these reasons, only suitably trained medical personnel should give thiopental in an environment … See more inclusion\u0027s c0Web925 rows · Identification Summary. Thiopental is a barbiturate used to induce general anesthesia, treat convulsions, and reduce intracranial pressure.. Generic Name Thiopental DrugBank Accession Number DB00599 Background. A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete … inclusion\u0027s c1WebOct 1, 2004 · Thiopental. In obese patients, thiopental has an increased Vd and a longer elimination half life (t 1/2), but Cl values are unchanged. It was stated in as long ago as 1969 that thiopental dosage should be based on LBM. However, Buckley and colleagues suggested a higher dose (7.5 mg kg −1) for induction based on IBW. The requirement for … incarnation is everywhere